General Information

  • ID:  hor002693
  • Uniprot ID:  H2KZL2
  • Protein name:  NLP-9
  • Gene name:  nlp-9
  • Organism:  Caenorhabditis elegans
  • Family:  NA
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  NA

Sequence Information

  • Sequence:  DQAAALPYYLYE
  • Length:  12(63-74)
  • Propeptide:  MDRFATRFIALLLVLLQIGSIFATPIAEAQGAPEDVDDRRELEKRGGARAFYGFYNAGNSKRDQAAALPYYLYEKRGGGRAFNHNANLFRFDKRGGGRAFAGSWSPYLERFYDYKRSSYPVYFSDNSYY
  • Signal peptide:  MDRFATRFIALLLVLLQIGSIFA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-H2KZL2-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002693_AF2.pdbhor002693_ESM.pdb

Physical Information

Mass: 161295 Formula: C67H93N13O21
Absent amino acids: CFGHIKMNRSTVW Common amino acids: AY
pI: 3.55 Basic residues: 0
Polar residues: 3 Hydrophobic residues: 5
Hydrophobicity: -25 Boman Index: -622
Half-Life / Aliphatic Index: 1.1 hour Aliphatic Index: 90
Instability Index: 2921.67 Extinction Coefficient cystines: 4470
Absorbance 280nm: 406.36

Literature

  • PubMed ID:  17564681
  • Title:  Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry.